Assay Detail
Binding
CHEMBL732636
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Inhibitory activity against Mitogen-activated protein kinase p38 (MAP kinase)
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.91 | 9.01 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL446404 | — | — | 1 | 9.01 |
| CHEMBL307435 | — | — | 1 | 8.82 |
| CHEMBL69764 | — | — | 1 | 8.05 |
| CHEMBL67874 | — | — | 1 | 7.72 |
| CHEMBL69929 | — | — | 1 | 7.55 |
| CHEMBL68572 | — | — | 1 | 7.42 |
| CHEMBL430419 | — | — | 1 | 7.32 |
| CHEMBL302728 | — | — | 1 | 7.24 |
| CHEMBL69331 | — | — | 1 | 7.16 |
| CHEMBL67633 | — | — | 1 | 6.92 |
| CHEMBL401695 | — | — | 1 | 6.89 |
| CHEMBL70286 | — | — | 1 | 6.86 |
| CHEMBL304624 | — | — | 1 | 6.85 |
| CHEMBL404842 | — | — | 1 | 6.82 |
| CHEMBL63135 | — | — | 1 | 6.77 |
| CHEMBL69228 | — | — | 1 | 6.75 |
| CHEMBL304166 | — | — | 1 | 6.70 |
| CHEMBL402426 | — | — | 1 | 6.52 |
| CHEMBL71955 | — | — | 1 | 6.30 |
| CHEMBL305023 | — | — | 1 | 6.26 |
| CHEMBL302805 | — | — | 1 | 6.16 |
| CHEMBL307340 | — | — | 1 | 6.01 |
| CHEMBL71987 | — | — | 1 | 6.00 |
| CHEMBL305749 | — | — | 1 | 5.91 |
| CHEMBL68215 | — | — | 1 | 5.85 |
| CHEMBL71922 | — | — | 1 | 5.68 |
| CHEMBL71403 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL446404 | — | IC50 | = | 0.97 | nM | 9.01 |
| CHEMBL307435 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL69764 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL67874 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL69929 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL68572 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL430419 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL302728 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL69331 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL67633 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL401695 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL70286 | — | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL304624 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL404842 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL63135 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL69228 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL304166 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL402426 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL71955 | — | IC50 | = | 495.0 | nM | 6.30 |
| CHEMBL305023 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL302805 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL307340 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL71987 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL305749 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL68215 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL71922 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL71403 | — | IC50 | > | 10000.0 | nM | - |