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Assay Detail

CHEMBL732792

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Binding
In vitro binding affinity towards human motilin receptor
12
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Motilin receptor (CHEMBL2203)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of a potent and novel motilin agonist.
Li JJ, Chao HG, Wang H, Tino JA, Lawrence RM, Ewing WR, Ma Z, Yan M, Slusarchyk D, Seethala R, Sun H, Li D, Burford NT, Stoffel RH, Salyan ME, Li CY, Witkus M, Zhao N, Rich A, Gordon DA.
J Med Chem (2004) 47 : 1704 -1708
PubMed 15027861 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 12 7.50 9.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL297494 2 9.15
CHEMBL296748 1 8.70
CHEMBL298224 1 8.57
CHEMBL2372767 MOTILIN 1 8.51
CHEMBL1628277 1 8.47
CHEMBL45905 3 5.39
CHEMBL532 ERYTHROMYCIN 4.0 1 4.43
CHEMBL46272 1 -
CHEMBL33827 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL297494 Ki = 0.7 nM 9.15
CHEMBL297494 Ki = 1.0 nM 9.00
CHEMBL296748 Ki = 2.0 nM 8.70
CHEMBL298224 Ki = 2.7 nM 8.57
CHEMBL2372767 MOTILIN Ki = 3.1 nM 8.51
CHEMBL1628277 Ki = 3.4 nM 8.47
CHEMBL45905 Ki = 4100.0 nM 5.39
CHEMBL45905 Ki = 5800.0 nM 5.24
CHEMBL532 ERYTHROMYCIN Ki = 37000.0 nM 4.43
CHEMBL46272 Ki > 10000.0 nM -
CHEMBL33827 Ki > 10000.0 nM -
CHEMBL45905 Ki > 10000.0 nM -