Compound Detail
CHEMBL2372767
MOTILIN Enter ChEMBL ID:
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CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)O)[C@@H](C)O
Basic Information
| ChEMBL ID | CHEMBL2372767 |
| Name | MOTILIN |
| Phase | Preclinical |
| Structure Type | BOTH |
| InChI Key | LVRVABPNVHYXRT-ZDDRDDBCSA-N |
1
Targets
3
Activities
2
Assay Types
1
PK Parameters
4
Publications
0
Known Names
Molecular Properties
2699.1
MW (Da)
Drug Information
| Molecule Type | Protein |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 9.44
EC50 1 meas. best 9.82
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Motilin receptor CHEMBL2203 | EC50 | 9.82 | 9.82 | 0.1 | 1 |
| Motilin receptor CHEMBL2203 | Ki | 9.44 | 8.975 | 0.4 | 2 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| T1/2 | 0.15 | hr | Oryctolagus cuniculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Motilin receptor | EC50 | = | 0.15 | nM | 9.82 | In vitro effective concentration towards human motilin receptor | 15027861 |
| Motilin receptor | Ki | = | 0.36 | nM | 9.44 | Displacement of [125I]motilin from human MOTR | 17125271 |
| Motilin receptor | Ki | = | 3.1 | nM | 8.51 | In vitro binding affinity towards human motilin receptor | 15027861 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15027861 | 10.1021/jm0304865 | Motilin receptor | 2 |
| 17125271 | 10.1021/jm0606600 | Motilin receptor | 1 |
| 18980843 | 10.1016/j.bmcl.2008.10.071 | Stomach | 1 |
| 18980843 | 10.1016/j.bmcl.2008.10.071 | ADMET | 1 |
Data from ChEMBL 36 via Core Engine