Assay Detail
Binding
CHEMBL732795
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Compound was tested for in vitro motilin receptor binding affinity after treatment with hydrochloric acid solution (pH 2.5)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Macrolide-type motilin receptor agonists: Acid-stable 12-O-methyl-8,9-anhydroerythromycin A 6,9-hemiacetals
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.20 | 8.08 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL262052 | — | — | 1 | 8.08 |
| CHEMBL351216 | — | — | 1 | 7.82 |
| CHEMBL166642 | — | — | 1 | 7.40 |
| CHEMBL532 | ERYTHROMYCIN | 4.0 | 1 | 7.15 |
| CHEMBL281952 | — | — | 1 | 6.77 |
| CHEMBL300004 | — | — | 1 | 6.65 |
| CHEMBL353526 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL262052 | — | IC50 | = | 8.318 | nM | 8.08 |
| CHEMBL351216 | — | IC50 | = | 15.14 | nM | 7.82 |
| CHEMBL166642 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL532 | ERYTHROMYCIN | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL281952 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL300004 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL353526 | — | IC50 | = | 302.0 | nM | 6.52 |