Assay Detail
Binding
CHEMBL732797
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Concentration required for in vitro acid stability with hydrochloric acid solution (pH 2.5 ) at room temperature for 2 hr by assaying the solution for motilin receptor binding
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Potent, acid-stable and orally active macrolide-type motilin receptor agonists, GM-611 and the derivatives
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.35 | 8.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL265495 | — | — | 1 | 8.19 |
| CHEMBL27424 | — | — | 1 | 8.10 |
| CHEMBL27419 | — | — | 1 | 8.05 |
| CHEMBL406517 | — | — | 1 | 7.15 |
| CHEMBL281952 | — | — | 1 | 6.77 |
| CHEMBL300004 | — | — | 1 | 6.65 |
| CHEMBL26966 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL265495 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL27424 | — | IC50 | = | 7.943 | nM | 8.10 |
| CHEMBL27419 | — | IC50 | = | 8.913 | nM | 8.05 |
| CHEMBL406517 | — | IC50 | = | 70.79 | nM | 7.15 |
| CHEMBL281952 | — | IC50 | = | 169.82 | nM | 6.77 |
| CHEMBL300004 | — | IC50 | = | 223.87 | nM | 6.65 |
| CHEMBL26966 | — | IC50 | = | 302.0 | nM | 6.52 |