Assay Detail
Binding
CHEMBL732887
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Inhibitory activity against mitogen-activated protein kinase p38 at 10 e-4 to 10 e-8 M concentration
33
Total Activities
33
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel substituted pyridinyl imidazoles as potent anticytokine agents with low activity against hepatic cytochrome P450 enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 33 | 5.99 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL321494 | — | — | 1 | 6.89 |
| CHEMBL320130 | — | — | 1 | 6.66 |
| CHEMBL324977 | — | — | 1 | 6.66 |
| CHEMBL109580 | — | — | 1 | 6.62 |
| CHEMBL109732 | — | — | 1 | 6.57 |
| CHEMBL10 | SB-203580 | — | 1 | 6.54 |
| CHEMBL109331 | — | — | 1 | 6.47 |
| CHEMBL323734 | — | — | 1 | 6.47 |
| CHEMBL111364 | — | — | 1 | 6.42 |
| CHEMBL322296 | — | — | 1 | 6.42 |
| CHEMBL432798 | — | — | 1 | 6.30 |
| CHEMBL111210 | — | — | 1 | 6.25 |
| CHEMBL113419 | — | — | 1 | 6.20 |
| CHEMBL109028 | — | — | 1 | 6.19 |
| CHEMBL111053 | — | — | 1 | 6.16 |
| CHEMBL110947 | — | — | 1 | 6.16 |
| CHEMBL109695 | — | — | 1 | 6.10 |
| CHEMBL110263 | — | — | 1 | 6.08 |
| CHEMBL321415 | — | — | 1 | 6.05 |
| CHEMBL320695 | — | — | 1 | 6.03 |
| CHEMBL321676 | — | — | 1 | 6.02 |
| CHEMBL111644 | — | — | 1 | 5.85 |
| CHEMBL109570 | — | — | 1 | 5.84 |
| CHEMBL325597 | — | — | 1 | 5.66 |
| CHEMBL109352 | — | — | 1 | 5.66 |
| CHEMBL332021 | — | — | 1 | 5.64 |
| CHEMBL111403 | — | — | 1 | 5.42 |
| CHEMBL111456 | — | — | 1 | 5.40 |
| CHEMBL110262 | — | — | 1 | 5.38 |
| CHEMBL321601 | — | — | 1 | 5.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL321494 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL320130 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL324977 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL109580 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL109732 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL10 | SB-203580 | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL109331 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL323734 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL111364 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL322296 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL432798 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL111210 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL113419 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL109028 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL110947 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL111053 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL109695 | — | IC50 | = | 790.0 | nM | 6.10 |
| CHEMBL110263 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL321415 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL320695 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL321676 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL111644 | — | IC50 | = | 1420.0 | nM | 5.85 |
| CHEMBL109570 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL325597 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL109352 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL332021 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL111403 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL111456 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL110262 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL321601 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL111566 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL323479 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL111279 | — | IC50 | = | 27000.0 | nM | 4.57 |