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Assay Detail

CHEMBL732894

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Binding
Inhibition of Mitogen-activated protein kinase p38
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

MAP kinase p38 (CHEMBL2094115)
Type PROTEIN FAMILY
Organism Homo sapiens

Publication

Pyridazine based inhibitors of p38 MAPK.
McIntyre CJ, Ponticello GS, Liverton NJ, O'Keefe SJ, O'Neill EA, Pang M, Schwartz CD, Claremon DA.
Bioorg Med Chem Lett (2002) 12 : 689 -692
PubMed 11844702 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 10 8.45 9.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL305178 1 9.96
CHEMBL545353 1 9.82
CHEMBL161276 1 9.22
CHEMBL161477 1 8.85
CHEMBL348754 1 8.72
CHEMBL349524 1 8.60
CHEMBL162295 1 8.59
CHEMBL161137 1 8.13
CHEMBL159698 1 7.70
CHEMBL305749 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL305178 IC50 = 0.11 nM 9.96
CHEMBL545353 IC50 = 0.15 nM 9.82
CHEMBL161276 IC50 = 0.6 nM 9.22
CHEMBL161477 IC50 = 1.4 nM 8.85
CHEMBL348754 IC50 = 1.9 nM 8.72
CHEMBL349524 IC50 = 2.5 nM 8.60
CHEMBL162295 IC50 = 2.6 nM 8.59
CHEMBL161137 IC50 = 7.4 nM 8.13
CHEMBL159698 IC50 = 20.1 nM 7.70
CHEMBL305749 IC50 = 12000.0 nM 4.92