Assay Detail
Binding
CHEMBL733082
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Inhibitory effect on Monoamine oxidase B, SD on IC50 values < 10%
59
Total Activities
58
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidases by functionalized coumarin derivatives: biological activities, QSARs, and 3D-QSARs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 59 | 7.12 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325761 | — | — | 1 | 8.94 |
| CHEMBL356977 | — | — | 1 | 8.59 |
| CHEMBL274030 | — | — | 1 | 8.59 |
| CHEMBL108697 | — | — | 1 | 8.55 |
| CHEMBL276076 | — | — | 1 | 8.52 |
| CHEMBL108928 | — | — | 1 | 8.52 |
| CHEMBL109018 | — | — | 1 | 8.48 |
| CHEMBL142799 | — | — | 1 | 8.46 |
| CHEMBL146222 | — | — | 1 | 8.46 |
| CHEMBL111310 | — | — | 1 | 8.44 |
| CHEMBL145792 | — | — | 1 | 8.43 |
| CHEMBL111309 | — | — | 2 | 8.36 |
| CHEMBL109085 | — | — | 1 | 8.36 |
| CHEMBL109084 | — | — | 1 | 8.25 |
| CHEMBL143555 | — | — | 1 | 8.24 |
| CHEMBL357614 | — | — | 1 | 8.23 |
| CHEMBL18966 | — | — | 1 | 8.21 |
| CHEMBL145217 | — | — | 1 | 8.19 |
| CHEMBL142923 | — | — | 1 | 8.13 |
| CHEMBL142582 | — | — | 1 | 8.07 |
| CHEMBL107541 | — | — | 1 | 8.06 |
| CHEMBL107488 | — | — | 1 | 8.01 |
| CHEMBL356714 | — | — | 1 | 7.97 |
| CHEMBL145003 | — | — | 1 | 7.94 |
| CHEMBL145503 | — | — | 1 | 7.88 |
| CHEMBL108660 | — | — | 1 | 7.74 |
| CHEMBL342327 | — | — | 1 | 7.64 |
| CHEMBL422830 | — | — | 1 | 7.55 |
| CHEMBL142916 | — | — | 1 | 7.55 |
| CHEMBL320251 | — | — | 1 | 7.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325761 | — | IC50 | = | 1.148 | nM | 8.94 |
| CHEMBL356977 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL274030 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL108697 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL276076 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL108928 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL109018 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL142799 | — | IC50 | = | 3.467 | nM | 8.46 |
| CHEMBL146222 | — | IC50 | = | 3.467 | nM | 8.46 |
| CHEMBL111310 | — | IC50 | = | 3.631 | nM | 8.44 |
| CHEMBL145792 | — | IC50 | = | 3.715 | nM | 8.43 |
| CHEMBL111309 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL109085 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL109084 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL143555 | — | IC50 | = | 5.754 | nM | 8.24 |
| CHEMBL357614 | — | IC50 | = | 5.888 | nM | 8.23 |
| CHEMBL18966 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL145217 | — | IC50 | = | 6.457 | nM | 8.19 |
| CHEMBL142923 | — | IC50 | = | 7.413 | nM | 8.13 |
| CHEMBL142582 | — | IC50 | = | 8.511 | nM | 8.07 |
| CHEMBL107541 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL107488 | — | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL356714 | — | IC50 | = | 10.72 | nM | 7.97 |
| CHEMBL145003 | — | IC50 | = | 11.48 | nM | 7.94 |
| CHEMBL145503 | — | IC50 | = | 13.18 | nM | 7.88 |
| CHEMBL108660 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL342327 | — | IC50 | = | 22.91 | nM | 7.64 |
| CHEMBL422830 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL142916 | — | IC50 | = | 28.18 | nM | 7.55 |
| CHEMBL320251 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL145292 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL145781 | 7-BENZYLOXYCOUMARIN | IC50 | = | 54.95 | nM | 7.26 |
| CHEMBL434695 | — | IC50 | = | 85.11 | nM | 7.07 |
| CHEMBL111264 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL348922 | — | IC50 | = | 162.18 | nM | 6.79 |
| CHEMBL142738 | — | IC50 | = | 190.55 | nM | 6.72 |
| CHEMBL144898 | — | IC50 | = | 234.42 | nM | 6.63 |
| CHEMBL439811 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL359392 | — | IC50 | = | 323.59 | nM | 6.49 |
| CHEMBL342357 | — | IC50 | = | 389.05 | nM | 6.41 |
| CHEMBL356734 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL323988 | — | IC50 | = | 562.34 | nM | 6.25 |
| CHEMBL145349 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL144960 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL145059 | — | IC50 | = | 1047.13 | nM | 5.98 |
| CHEMBL145403 | — | IC50 | = | 1380.38 | nM | 5.86 |
| CHEMBL141326 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL145290 | — | IC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL434510 | — | IC50 | = | 2041.74 | nM | 5.69 |
| CHEMBL143316 | — | IC50 | = | 2137.96 | nM | 5.67 |