Assay Detail
Binding
CHEMBL733083
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Inhibitory activity against monoamine oxidase B
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Coumarins derivatives as dual inhibitors of acetylcholinesterase and monoamine oxidase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 8.10 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325761 | — | — | 1 | 8.94 |
| CHEMBL274030 | — | — | 1 | 8.59 |
| CHEMBL108697 | — | — | 1 | 8.55 |
| CHEMBL108928 | — | — | 1 | 8.52 |
| CHEMBL276076 | — | — | 1 | 8.52 |
| CHEMBL109018 | — | — | 1 | 8.48 |
| CHEMBL111310 | — | — | 1 | 8.44 |
| CHEMBL109085 | — | — | 1 | 8.36 |
| CHEMBL111309 | — | — | 1 | 8.36 |
| CHEMBL109084 | — | — | 1 | 8.25 |
| CHEMBL18966 | — | — | 1 | 8.21 |
| CHEMBL107541 | — | — | 1 | 8.06 |
| CHEMBL107488 | — | — | 1 | 8.01 |
| CHEMBL108660 | — | — | 1 | 7.74 |
| CHEMBL320251 | — | — | 1 | 7.46 |
| CHEMBL111264 | — | — | 1 | 6.90 |
| CHEMBL323988 | — | — | 1 | 6.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325761 | — | IC50 | = | 1.148 | nM | 8.94 |
| CHEMBL274030 | — | IC50 | = | 2.57 | nM | 8.59 |
| CHEMBL108697 | — | IC50 | = | 2.818 | nM | 8.55 |
| CHEMBL108928 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL276076 | — | IC50 | = | 3.02 | nM | 8.52 |
| CHEMBL109018 | — | IC50 | = | 3.311 | nM | 8.48 |
| CHEMBL111310 | — | IC50 | = | 3.631 | nM | 8.44 |
| CHEMBL109085 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL111309 | — | IC50 | = | 4.365 | nM | 8.36 |
| CHEMBL109084 | — | IC50 | = | 5.623 | nM | 8.25 |
| CHEMBL18966 | — | IC50 | = | 6.166 | nM | 8.21 |
| CHEMBL107541 | — | IC50 | = | 8.71 | nM | 8.06 |
| CHEMBL107488 | — | IC50 | = | 9.772 | nM | 8.01 |
| CHEMBL108660 | — | IC50 | = | 18.2 | nM | 7.74 |
| CHEMBL320251 | — | IC50 | = | 34.67 | nM | 7.46 |
| CHEMBL111264 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL323988 | — | IC50 | = | 562.34 | nM | 6.25 |