Assay Detail
Binding
CHEMBL733084
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Inhibitory activity against Monoamine oxidase B from rat brain mitochondria
13
Total Activities
13
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Mitochondria |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.01 | 7.05 |
| Log IC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127983 | — | — | 1 | 7.05 |
| CHEMBL124935 | — | — | 1 | 6.30 |
| CHEMBL123803 | — | — | 1 | 6.20 |
| CHEMBL127757 | — | — | 1 | 5.00 |
| CHEMBL339627 | — | — | 1 | 4.94 |
| CHEMBL421088 | — | — | 1 | 4.68 |
| CHEMBL341240 | — | — | 1 | 4.61 |
| CHEMBL124867 | — | — | 1 | 4.56 |
| CHEMBL339794 | — | — | 1 | 4.49 |
| CHEMBL341071 | — | — | 1 | 4.12 |
| CHEMBL123895 | — | — | 1 | 4.10 |
| CHEMBL127880 | — | — | 1 | 4.03 |
| CHEMBL123795 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127983 | — | IC50 | = | 89.13 | nM | 7.05 |
| CHEMBL124935 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL123803 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL127757 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL339627 | — | IC50 | = | 11481.54 | nM | 4.94 |
| CHEMBL421088 | — | IC50 | = | 20892.96 | nM | 4.68 |
| CHEMBL341240 | — | IC50 | = | 24547.09 | nM | 4.61 |
| CHEMBL124867 | — | IC50 | = | 27542.29 | nM | 4.56 |
| CHEMBL339794 | — | IC50 | = | 32359.37 | nM | 4.49 |
| CHEMBL341071 | — | IC50 | = | 75857.76 | nM | 4.12 |
| CHEMBL123895 | — | IC50 | = | 79432.82 | nM | 4.10 |
| CHEMBL127880 | — | IC50 | = | 93325.43 | nM | 4.03 |
| CHEMBL123795 | — | Log IC50 | = | - | — | - |