Assay Detail
Binding
CHEMBL733086
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Monoamine oxidase B
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibition of monoamine oxidase-B by condensed pyridazines and pyrimidines: effects of lipophilicity and structure-activity relationships.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.29 | 6.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL127517 | — | — | 1 | 6.04 |
| CHEMBL340701 | — | — | 1 | 6.04 |
| CHEMBL125094 | — | — | 1 | 5.80 |
| CHEMBL125044 | — | — | 1 | 5.49 |
| CHEMBL127518 | — | — | 1 | 4.80 |
| CHEMBL127966 | — | — | 1 | 4.74 |
| CHEMBL340952 | — | — | 1 | 4.13 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL127517 | — | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL340701 | — | IC50 | = | 912.01 | nM | 6.04 |
| CHEMBL125094 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL125044 | — | IC50 | = | 3235.94 | nM | 5.49 |
| CHEMBL127518 | — | IC50 | = | 15848.93 | nM | 4.80 |
| CHEMBL127966 | — | IC50 | = | 18197.01 | nM | 4.74 |
| CHEMBL340952 | — | IC50 | = | 74131.02 | nM | 4.13 |