Assay Detail
Binding
CHEMBL733334
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo inhibition of murine Mitogen-activated protein kinase p38 alpha activity, GST-ATF-2 as substrate in the presence of 120 uM ATP
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
SAR of 2,6-diamino-3,5-difluoropyridinyl substituted heterocycles as novel p38MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.54 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL304523 | — | — | 1 | 8.40 |
| CHEMBL306667 | — | — | 1 | 8.40 |
| CHEMBL66600 | — | — | 1 | 8.30 |
| CHEMBL63983 | — | — | 1 | 7.80 |
| CHEMBL63442 | — | — | 1 | 7.05 |
| CHEMBL65541 | — | — | 1 | 6.85 |
| CHEMBL291427 | — | — | 1 | 6.68 |
| CHEMBL307336 | — | — | 1 | 6.40 |
| CHEMBL304416 | — | — | 1 | 6.33 |
| CHEMBL66601 | — | — | 1 | 6.17 |
| CHEMBL66802 | — | — | 1 | 6.10 |
| CHEMBL294052 | — | — | 1 | 6.10 |
| CHEMBL63135 | — | — | 1 | 6.00 |
| CHEMBL295787 | — | — | 1 | 5.89 |
| CHEMBL291834 | — | — | 1 | 5.68 |
| CHEMBL305797 | — | — | 1 | 5.00 |
| CHEMBL419069 | — | — | 1 | 4.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL304523 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL306667 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL66600 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL63983 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL63442 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL65541 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL291427 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL307336 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL304416 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL66601 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL66802 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL294052 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL63135 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL295787 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL291834 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL305797 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL419069 | — | IC50 | = | 100000.0 | nM | 4.00 |