Assay Detail
Binding
CHEMBL733335
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of murine p38 alpha kinase
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Imidazopyrimidines, potent inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.36 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333923 | — | — | 1 | 9.00 |
| CHEMBL119595 | — | — | 1 | 8.70 |
| CHEMBL119695 | — | — | 1 | 8.22 |
| CHEMBL122061 | — | — | 1 | 8.10 |
| CHEMBL331252 | — | — | 1 | 8.10 |
| CHEMBL331215 | — | — | 1 | 7.66 |
| CHEMBL432839 | — | — | 1 | 7.43 |
| CHEMBL115509 | — | — | 1 | 6.68 |
| CHEMBL119849 | — | — | 1 | 6.34 |
| CHEMBL119648 | — | — | 1 | 6.24 |
| CHEMBL326748 | — | — | 1 | 6.00 |
| CHEMBL115769 | — | — | 1 | 5.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333923 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL119595 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL119695 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL122061 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL331252 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL331215 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL432839 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL115509 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL119849 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL119648 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL326748 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL115769 | — | IC50 | = | 1500.0 | nM | 5.82 |