Assay Detail
Binding
CHEMBL733336
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Kd value and murine Mitogen-activated protein kinase p38 alpha complex was calculated
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of the p38alpha MAP kinase inhibitor 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)naph- thalen-1-yl]urea (BIRB 796).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 27 | 8.58 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 10.34 |
| CHEMBL336001 | — | — | 1 | 10.13 |
| CHEMBL143886 | — | — | 1 | 10.02 |
| CHEMBL143134 | — | — | 1 | 10.00 |
| CHEMBL344625 | — | — | 1 | 9.80 |
| CHEMBL104991 | — | — | 1 | 9.74 |
| CHEMBL344800 | — | — | 1 | 9.64 |
| CHEMBL318810 | — | — | 1 | 9.64 |
| CHEMBL142115 | — | — | 1 | 9.40 |
| CHEMBL343227 | — | — | 1 | 9.28 |
| CHEMBL143373 | — | — | 1 | 9.06 |
| CHEMBL139991 | — | — | 1 | 8.82 |
| CHEMBL348228 | — | — | 1 | 8.72 |
| CHEMBL105248 | — | — | 1 | 8.47 |
| CHEMBL143141 | — | — | 1 | 8.46 |
| CHEMBL143207 | — | — | 1 | 8.23 |
| CHEMBL342523 | — | — | 1 | 8.00 |
| CHEMBL342952 | — | — | 1 | 7.96 |
| CHEMBL336681 | — | — | 1 | 7.92 |
| CHEMBL424107 | — | — | 1 | 7.85 |
| CHEMBL10 | SB-203580 | — | 1 | 7.70 |
| CHEMBL423196 | — | — | 1 | 7.64 |
| CHEMBL104749 | — | — | 1 | 7.58 |
| CHEMBL107850 | — | — | 1 | 7.25 |
| CHEMBL141294 | — | — | 1 | 7.19 |
| CHEMBL341559 | — | — | 1 | 7.19 |
| CHEMBL104119 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 0.046 | nM | 10.34 |
| CHEMBL336001 | — | Kd | = | 0.074 | nM | 10.13 |
| CHEMBL143886 | — | Kd | = | 0.096 | nM | 10.02 |
| CHEMBL143134 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL344625 | — | Kd | = | 0.16 | nM | 9.80 |
| CHEMBL104991 | — | Kd | = | 0.18 | nM | 9.74 |
| CHEMBL344800 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL318810 | — | Kd | = | 0.23 | nM | 9.64 |
| CHEMBL142115 | — | Kd | = | 0.4 | nM | 9.40 |
| CHEMBL343227 | — | Kd | = | 0.52 | nM | 9.28 |
| CHEMBL143373 | — | Kd | = | 0.87 | nM | 9.06 |
| CHEMBL139991 | — | Kd | = | 1.5 | nM | 8.82 |
| CHEMBL348228 | — | Kd | = | 1.9 | nM | 8.72 |
| CHEMBL105248 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL143141 | — | Kd | = | 3.5 | nM | 8.46 |
| CHEMBL143207 | — | Kd | = | 5.9 | nM | 8.23 |
| CHEMBL342523 | — | Kd | = | 9.9 | nM | 8.00 |
| CHEMBL342952 | — | Kd | = | 11.0 | nM | 7.96 |
| CHEMBL336681 | — | Kd | = | 12.0 | nM | 7.92 |
| CHEMBL424107 | — | Kd | = | 14.0 | nM | 7.85 |
| CHEMBL10 | SB-203580 | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL423196 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL104749 | — | Kd | = | 26.0 | nM | 7.58 |
| CHEMBL107850 | — | Kd | = | 56.0 | nM | 7.25 |
| CHEMBL141294 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL341559 | — | Kd | = | 64.0 | nM | 7.19 |
| CHEMBL104119 | — | Kd | = | 2400.0 | nM | 5.62 |