Assay Detail
Binding
CHEMBL733338
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Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcription factor-2).
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Hybrid-designed inhibitors of p38 MAP kinase utilizing N-arylpyridazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.25 | 8.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334215 | — | — | 1 | 8.10 |
| CHEMBL325854 | — | — | 1 | 8.10 |
| CHEMBL118651 | — | — | 1 | 8.05 |
| CHEMBL118466 | — | — | 1 | 7.85 |
| CHEMBL118768 | — | — | 1 | 7.85 |
| CHEMBL325706 | — | — | 1 | 7.66 |
| CHEMBL119385 | NEFLAMAPIMOD | 2.0 | 1 | 7.66 |
| CHEMBL333243 | — | — | 1 | 7.66 |
| CHEMBL118187 | — | — | 1 | 7.58 |
| CHEMBL434409 | — | — | 1 | 7.38 |
| CHEMBL117109 | — | — | 1 | 7.31 |
| CHEMBL334184 | — | — | 1 | 7.12 |
| CHEMBL119675 | — | — | 1 | 6.77 |
| CHEMBL118917 | — | — | 1 | 6.68 |
| CHEMBL331842 | — | — | 1 | 6.57 |
| CHEMBL119406 | — | — | 1 | 6.46 |
| CHEMBL332666 | — | — | 1 | 6.00 |
| CHEMBL117228 | — | — | 1 | 5.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334215 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL325854 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL118651 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL118466 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL118768 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL325706 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL119385 | NEFLAMAPIMOD | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL333243 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL118187 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL434409 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL117109 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL334184 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL119675 | — | IC50 | = | 171.0 | nM | 6.77 |
| CHEMBL118917 | — | IC50 | = | 208.0 | nM | 6.68 |
| CHEMBL331842 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL119406 | — | IC50 | = | 344.0 | nM | 6.46 |
| CHEMBL332666 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL117228 | — | IC50 | = | 2000.0 | nM | 5.70 |