Assay Detail
Functional
CHEMBL733698
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of LPS-stimulated TNF-alpha production in monocyte cells
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Design and synthesis of potent, orally bioavailable dihydroquinazolinone inhibitors of p38 MAP kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 8.50 | 9.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327746 | — | — | 1 | 9.15 |
| CHEMBL328614 | — | — | 1 | 9.00 |
| CHEMBL96653 | — | — | 1 | 8.89 |
| CHEMBL319556 | — | — | 1 | 8.89 |
| CHEMBL97227 | — | — | 1 | 8.85 |
| CHEMBL94825 | — | — | 1 | 8.80 |
| CHEMBL96763 | — | — | 1 | 8.70 |
| CHEMBL96487 | — | — | 1 | 8.54 |
| CHEMBL96225 | — | — | 1 | 8.42 |
| CHEMBL96432 | — | — | 1 | 8.35 |
| CHEMBL94417 | — | — | 1 | 8.11 |
| CHEMBL94444 | — | — | 1 | 7.94 |
| CHEMBL96565 | — | — | 1 | 7.78 |
| CHEMBL327217 | — | — | 1 | 7.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327746 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL328614 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL96653 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL319556 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL97227 | — | IC50 | = | 1.4 | nM | 8.85 |
| CHEMBL94825 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL96763 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL96487 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL96225 | — | IC50 | = | 3.8 | nM | 8.42 |
| CHEMBL96432 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL94417 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL94444 | — | IC50 | = | 11.4 | nM | 7.94 |
| CHEMBL96565 | — | IC50 | = | 16.6 | nM | 7.78 |
| CHEMBL327217 | — | IC50 | = | 26.8 | nM | 7.57 |