Assay Detail
Binding
CHEMBL733984
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Inhibitory activity against rat brain mitochondrial Monoamine oxidase B
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Amine oxidase [flavin-containing] B (CHEMBL2993) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Selective inhibitors of monoamine oxidase. 3. Structure-activity relationship of tricyclics bearing imidazoline, oxadiazole, or tetrazole groups.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.20 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL52887 | — | — | 1 | 7.22 |
| CHEMBL54762 | — | — | 1 | 7.00 |
| CHEMBL55674 | — | — | 1 | 7.00 |
| CHEMBL301087 | — | — | 1 | 6.00 |
| CHEMBL53617 | — | — | 1 | 5.00 |
| CHEMBL301625 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL52887 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL54762 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL55674 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL301087 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL53617 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL301625 | — | IC50 | = | 10000.0 | nM | 5.00 |