Assay Detail
Binding
CHEMBL734079
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Inhibition of Mitogen-activated protein kinase p38
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of potent, selective, and orally bioavailable tetrasubstituted imidazole inhibitors of p38 mitogen-activated protein kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.51 | 9.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL305178 | — | — | 1 | 9.96 |
| CHEMBL303144 | — | — | 1 | 9.72 |
| CHEMBL308939 | — | — | 1 | 9.12 |
| CHEMBL424418 | — | — | 1 | 8.15 |
| CHEMBL307980 | — | — | 1 | 8.12 |
| CHEMBL10 | SB-203580 | — | 1 | 7.41 |
| CHEMBL67658 | — | — | 1 | 7.07 |
| CHEMBL431583 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL305178 | — | IC50 | = | 0.11 | nM | 9.96 |
| CHEMBL303144 | — | IC50 | = | 0.19 | nM | 9.72 |
| CHEMBL308939 | — | IC50 | = | 0.75 | nM | 9.12 |
| CHEMBL424418 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL307980 | — | IC50 | = | 7.6 | nM | 8.12 |
| CHEMBL10 | SB-203580 | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL67658 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL431583 | — | IC50 | > | 10000.0 | nM | - |