Assay Detail
Binding
CHEMBL734085
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Dissociation constant at Tm against human Mitogen-activated protein kinase p38 alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 7.01 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 8.89 |
| CHEMBL143134 | — | — | 1 | 8.62 |
| CHEMBL318810 | — | — | 1 | 8.28 |
| CHEMBL105248 | — | — | 1 | 7.20 |
| CHEMBL420047 | — | — | 1 | 6.93 |
| CHEMBL315100 | — | — | 1 | 6.75 |
| CHEMBL104749 | — | — | 1 | 6.68 |
| CHEMBL444613 | — | — | 1 | 6.31 |
| CHEMBL87277 | — | — | 1 | 5.23 |
| CHEMBL104119 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 1.3 | nM | 8.89 |
| CHEMBL143134 | — | Kd | = | 2.4 | nM | 8.62 |
| CHEMBL318810 | — | Kd | = | 5.3 | nM | 8.28 |
| CHEMBL105248 | — | Kd | = | 62.8 | nM | 7.20 |
| CHEMBL420047 | — | Kd | = | 118.0 | nM | 6.93 |
| CHEMBL315100 | — | Kd | = | 177.0 | nM | 6.75 |
| CHEMBL104749 | — | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL444613 | — | Kd | = | 493.0 | nM | 6.31 |
| CHEMBL87277 | — | Kd | = | 5850.0 | nM | 5.23 |
| CHEMBL104119 | — | Kd | = | 6070.0 | nM | 5.22 |