Assay Detail
Binding
CHEMBL734086
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Dissociation constant at Tm against human Mitogen-activated protein kinase p38 alpha (constant fit)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 5 | 7.17 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL315100 | — | — | 1 | 8.30 |
| CHEMBL104749 | — | — | 1 | 8.00 |
| CHEMBL444613 | — | — | 1 | 7.70 |
| CHEMBL87277 | — | — | 1 | 5.94 |
| CHEMBL104119 | — | — | 1 | 5.93 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL315100 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL104749 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL444613 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL87277 | — | Kd | = | 1152.0 | nM | 5.94 |
| CHEMBL104119 | — | Kd | = | 1181.0 | nM | 5.93 |