Assay Detail
Binding
CHEMBL734087
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Dissociation constant at Tm against human Mitogen-activated protein kinase p38 alpha (fluorescence exchange curve)
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 8.36 | 10.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL318810 | — | — | 1 | 10.05 |
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 10.00 |
| CHEMBL143134 | — | — | 1 | 9.30 |
| CHEMBL420047 | — | — | 1 | 9.00 |
| CHEMBL105248 | — | — | 1 | 8.22 |
| CHEMBL315100 | — | — | 1 | 7.68 |
| CHEMBL104749 | — | — | 1 | 7.64 |
| CHEMBL444613 | — | — | 1 | 7.44 |
| CHEMBL87277 | — | — | 1 | 5.94 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL318810 | — | Kd | = | 0.09 | nM | 10.05 |
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL143134 | — | Kd | = | 0.5 | nM | 9.30 |
| CHEMBL420047 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL105248 | — | Kd | = | 6.0 | nM | 8.22 |
| CHEMBL315100 | — | Kd | = | 21.0 | nM | 7.68 |
| CHEMBL104749 | — | Kd | = | 23.0 | nM | 7.64 |
| CHEMBL444613 | — | Kd | = | 36.0 | nM | 7.44 |
| CHEMBL87277 | — | Kd | = | 1160.0 | nM | 5.94 |