Assay Detail
Binding
CHEMBL734088
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Dissociation constant at Tref against human Mitogen-activated protein kinase p38 alpha
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Thermal denaturation: a method to rank slow binding, high-affinity P38alpha MAP kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 8.04 | 10.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | 2.0 | 1 | 10.34 |
| CHEMBL143134 | — | — | 1 | 9.98 |
| CHEMBL318810 | — | — | 1 | 9.64 |
| CHEMBL105248 | — | — | 1 | 8.47 |
| CHEMBL420047 | — | — | 1 | 7.97 |
| CHEMBL315100 | — | — | 1 | 7.78 |
| CHEMBL104749 | — | — | 1 | 7.59 |
| CHEMBL444613 | — | — | 1 | 7.25 |
| CHEMBL87277 | — | — | 1 | 5.71 |
| CHEMBL104119 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL103667 | DORAMAPIMOD | Kd | = | 0.046 | nM | 10.34 |
| CHEMBL143134 | — | Kd | = | 0.104 | nM | 9.98 |
| CHEMBL318810 | — | Kd | = | 0.231 | nM | 9.64 |
| CHEMBL105248 | — | Kd | = | 3.4 | nM | 8.47 |
| CHEMBL420047 | — | Kd | = | 10.6 | nM | 7.97 |
| CHEMBL315100 | — | Kd | = | 16.8 | nM | 7.78 |
| CHEMBL104749 | — | Kd | = | 25.7 | nM | 7.59 |
| CHEMBL444613 | — | Kd | = | 56.4 | nM | 7.25 |
| CHEMBL87277 | — | Kd | = | 1950.0 | nM | 5.71 |
| CHEMBL104119 | — | Kd | = | 2400.0 | nM | 5.62 |