Assay Detail
Binding
CHEMBL734264
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Competitive inhibition against rat mitochondrial thymidine kinase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Species- or isozyme-specific enzyme inhibitors. 5. Differential effects of thymidine substituents on affinity for rat thymidine kinase isozymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 4.50 | 5.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3143486 | — | — | 1 | 5.10 |
| CHEMBL2111285 | — | — | 1 | 4.96 |
| CHEMBL22539 | — | — | 1 | 4.21 |
| CHEMBL3143491 | — | — | 1 | 4.14 |
| CHEMBL3143492 | — | — | 1 | 4.11 |
| CHEMBL157402 | — | — | 1 | - |
| CHEMBL991 | STAVUDINE | 4.0 | 1 | - |
| CHEMBL319447 | — | — | 1 | - |
| CHEMBL103356 | 3-AMINO- 3-DEOXYTHYMIDINE | — | 1 | - |
| CHEMBL156488 | — | — | 1 | - |
| CHEMBL444314 | — | — | 1 | - |
| CHEMBL66115 | DOXECITINE | 2.0 | 1 | - |
| CHEMBL3143490 | — | — | 1 | - |
| CHEMBL373855 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3143486 | — | Ki | = | 8000.0 | nM | 5.10 |
| CHEMBL2111285 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL22539 | — | Ki | = | 62000.0 | nM | 4.21 |
| CHEMBL3143491 | — | Ki | = | 72000.0 | nM | 4.14 |
| CHEMBL3143492 | — | Ki | = | 77000.0 | nM | 4.11 |
| CHEMBL157402 | — | Ki | = | 960000.0 | nM | - |
| CHEMBL991 | STAVUDINE | Ki | = | 3250000.0 | nM | - |
| CHEMBL319447 | — | Ki | = | 4600000.0 | nM | - |
| CHEMBL103356 | 3-AMINO- 3-DEOXYTHYMIDINE | Ki | = | 2600000.0 | nM | - |
| CHEMBL156488 | — | Ki | = | 1440000.0 | nM | - |
| CHEMBL444314 | — | Ki | = | 880000.0 | nM | - |
| CHEMBL66115 | DOXECITINE | Ki | = | 320000.0 | nM | - |
| CHEMBL3143490 | — | Ki | = | 1100000.0 | nM | - |
| CHEMBL373855 | — | Ki | = | 250000.0 | nM | - |