Assay Detail
Functional
CHEMBL735750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of electrically evoked contraction of guinea pig ileum (myenteric plexus;longitudinal muscle)[agonist action at mu 1 opioid receptors) and inhibition of electrically evoked contraction of mouse vas deferens (agonist action at delta 1 opioid receptor)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Investigation of the structural parameters involved in the mu and delta opioid receptor discrimination of linear enkephalin-related peptides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.66 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2370601 | — | — | 1 | 10.30 |
| CHEMBL127378 | — | — | 1 | 9.82 |
| CHEMBL125564 | — | — | 1 | 9.60 |
| CHEMBL124283 | — | — | 1 | 9.40 |
| CHEMBL127711 | — | — | 1 | 9.39 |
| CHEMBL2370602 | — | — | 1 | 8.96 |
| CHEMBL341480 | — | — | 1 | 8.88 |
| CHEMBL338307 | — | — | 1 | 8.61 |
| CHEMBL31421 | — | — | 1 | 8.60 |
| CHEMBL125060 | — | — | 1 | 8.46 |
| CHEMBL338661 | — | — | 1 | 8.14 |
| CHEMBL339020 | — | — | 1 | 7.89 |
| CHEMBL333064 | — | — | 1 | 7.42 |
| CHEMBL38874 | DAMGO | — | 1 | 7.12 |
| CHEMBL2370600 | — | — | 1 | 6.98 |
| CHEMBL70 | MORPHINE | 4.0 | 1 | 6.51 |
| CHEMBL338773 | — | — | 1 | 6.13 |
| CHEMBL2370599 | — | — | 1 | 6.00 |
| CHEMBL419414 | — | — | 1 | 5.98 |
| CHEMBL123631 | — | — | 1 | 5.75 |
| CHEMBL341500 | — | — | 1 | 5.50 |
| CHEMBL275050 | — | — | 1 | 5.47 |
| CHEMBL339002 | — | — | 1 | 5.33 |
| CHEMBL14094 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2370601 | — | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL127378 | — | IC50 | = | 0.15 | nM | 9.82 |
| CHEMBL125564 | — | IC50 | = | 0.25 | nM | 9.60 |
| CHEMBL124283 | — | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL127711 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL2370602 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL341480 | — | IC50 | = | 1.33 | nM | 8.88 |
| CHEMBL338307 | — | IC50 | = | 2.45 | nM | 8.61 |
| CHEMBL31421 | — | IC50 | = | 2.5 | nM | 8.60 |
| CHEMBL125060 | — | IC50 | = | 3.45 | nM | 8.46 |
| CHEMBL338661 | — | IC50 | = | 7.3 | nM | 8.14 |
| CHEMBL339020 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL333064 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL38874 | DAMGO | IC50 | = | 76.1 | nM | 7.12 |
| CHEMBL2370600 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL70 | MORPHINE | IC50 | = | 309.0 | nM | 6.51 |
| CHEMBL338773 | — | IC50 | = | 733.0 | nM | 6.13 |
| CHEMBL2370599 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL419414 | — | IC50 | = | 1050.0 | nM | 5.98 |
| CHEMBL123631 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL341500 | — | IC50 | = | 3180.0 | nM | 5.50 |
| CHEMBL275050 | — | IC50 | = | 3410.0 | nM | 5.47 |
| CHEMBL339002 | — | IC50 | = | 4720.0 | nM | 5.33 |
| CHEMBL14094 | — | IC50 | >= | 50000.0 | nM | - |