Assay Detail
Functional
CHEMBL735758
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Tested for inhibition of amplification of electrically induced twitch in mouse vas deferens (MVD)
8
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.14 | 9.47 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | — | 1 | 9.47 |
| CHEMBL124941 | — | — | 2 | 9.42 |
| CHEMBL124435 | — | — | 1 | 9.39 |
| CHEMBL330991 | — | — | 1 | 6.81 |
| CHEMBL121946 | — | — | 2 | 6.30 |
| CHEMBL122159 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317956 | DELTORPHIN C | IC50 | = | 0.34 | nM | 9.47 |
| CHEMBL124941 | — | IC50 | = | 0.38 | nM | 9.42 |
| CHEMBL124435 | — | IC50 | = | 0.41 | nM | 9.39 |
| CHEMBL124941 | — | IC50 | = | 0.46 | nM | 9.34 |
| CHEMBL330991 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL121946 | — | IC50 | = | 498.0 | nM | 6.30 |
| CHEMBL121946 | — | IC50 | = | 554.0 | nM | 6.26 |
| CHEMBL122159 | — | IC50 | > | 10000.0 | nM | - |