Assay Detail
Functional
CHEMBL737141
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38 MAP kinase related TNF-alpha release from human whole blood
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Tissue | Blood |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
From imidazoles to pyrimidines: new inhibitors of cytokine release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 4.74 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 6.03 |
| CHEMBL313417 | — | — | 1 | 4.92 |
| CHEMBL111456 | — | — | 1 | 4.69 |
| CHEMBL143370 | — | — | 1 | 4.47 |
| CHEMBL358814 | — | — | 1 | 4.32 |
| CHEMBL92723 | — | — | 1 | 4.02 |
| CHEMBL92070 | — | — | 1 | - |
| CHEMBL94086 | — | — | 1 | - |
| CHEMBL92724 | — | — | 1 | - |
| CHEMBL93574 | — | — | 1 | - |
| CHEMBL93914 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL313417 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL111456 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL143370 | — | IC50 | = | 33500.0 | nM | 4.47 |
| CHEMBL358814 | — | IC50 | = | 47500.0 | nM | 4.32 |
| CHEMBL92723 | — | IC50 | = | 95500.0 | nM | 4.02 |
| CHEMBL92070 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL94086 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL92724 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL93574 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL93914 | — | IC50 | > | 100000.0 | nM | - |