Assay Detail
Functional
CHEMBL737142
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of p38 MAP kinase related TNF-alpha release from peripheral blood mononuclear cells (PBMC)
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
From imidazoles to pyrimidines: new inhibitors of cytokine release.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.03 | 7.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL10 | SB-203580 | — | 1 | 7.43 |
| CHEMBL441811 | — | — | 1 | 5.50 |
| CHEMBL111456 | — | — | 1 | 5.44 |
| CHEMBL313417 | — | — | 1 | 5.26 |
| CHEMBL93079 | — | — | 1 | 5.19 |
| CHEMBL92723 | — | — | 1 | 4.85 |
| CHEMBL358814 | — | — | 1 | 4.82 |
| CHEMBL92070 | — | — | 1 | 4.75 |
| CHEMBL143370 | — | — | 1 | 4.63 |
| CHEMBL93574 | — | — | 1 | 4.57 |
| CHEMBL94086 | — | — | 1 | 4.52 |
| CHEMBL92724 | — | — | 1 | 4.27 |
| CHEMBL93914 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL10 | SB-203580 | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL441811 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL111456 | — | IC50 | = | 3650.0 | nM | 5.44 |
| CHEMBL313417 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL93079 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL92723 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL358814 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL92070 | — | IC50 | = | 17800.0 | nM | 4.75 |
| CHEMBL143370 | — | IC50 | = | 23500.0 | nM | 4.63 |
| CHEMBL93574 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL94086 | — | IC50 | = | 29900.0 | nM | 4.52 |
| CHEMBL92724 | — | IC50 | = | 54000.0 | nM | 4.27 |
| CHEMBL93914 | — | IC50 | = | 60000.0 | nM | 4.22 |