Assay Detail
Binding
CHEMBL740206
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Tested in vitro for dopamine(DA) neuronal uptake inhibition
29
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Sodium-dependent dopamine transporter (CHEMBL2799) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Pyrroloisoquinoline antidepressants. 3. A focus on serotonin.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 6.91 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285506 | — | — | 1 | 9.00 |
| CHEMBL330666 | — | — | 1 | 8.59 |
| CHEMBL96362 | — | — | 1 | 8.49 |
| CHEMBL35184 | — | — | 1 | 7.95 |
| CHEMBL327790 | — | — | 3 | 7.63 |
| CHEMBL94535 | — | — | 1 | 7.56 |
| CHEMBL95153 | — | — | 1 | 7.36 |
| CHEMBL555462 | — | — | 1 | 7.24 |
| CHEMBL329216 | — | — | 1 | 7.08 |
| CHEMBL539803 | — | — | 1 | 7.08 |
| CHEMBL328818 | — | — | 1 | 7.07 |
| CHEMBL555655 | — | — | 1 | 6.99 |
| CHEMBL94508 | — | — | 1 | 6.96 |
| CHEMBL94738 | — | — | 1 | 6.89 |
| CHEMBL94665 | — | — | 1 | 6.73 |
| CHEMBL94711 | — | — | 1 | 6.56 |
| CHEMBL554191 | — | — | 1 | 6.54 |
| CHEMBL490 | PAROXETINE | 4.0 | 1 | 6.34 |
| CHEMBL541308 | — | — | 1 | 6.19 |
| CHEMBL94739 | FEMOXETINE | 2.0 | 1 | 5.99 |
| CHEMBL284305 | — | — | 1 | 5.76 |
| CHEMBL93035 | — | — | 1 | 5.68 |
| CHEMBL545724 | — | — | 1 | 5.55 |
| CHEMBL96615 | — | — | 1 | 5.21 |
| CHEMBL11 | IMIPRAMINE | 4.0 | 1 | - |
| CHEMBL41 | FLUOXETINE | 4.0 | 1 | - |
| CHEMBL549 | CITALOPRAM | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285506 | — | Ki | = | 0.99 | nM | 9.00 |
| CHEMBL330666 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL96362 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL35184 | — | Ki | = | 11.3 | nM | 7.95 |
| CHEMBL327790 | — | Ki | = | 23.5 | nM | 7.63 |
| CHEMBL94535 | — | Ki | = | 27.4 | nM | 7.56 |
| CHEMBL327790 | — | Ki | = | 36.8 | nM | 7.43 |
| CHEMBL95153 | — | Ki | = | 43.7 | nM | 7.36 |
| CHEMBL555462 | — | Ki | = | 57.7 | nM | 7.24 |
| CHEMBL329216 | — | Ki | = | 83.0 | nM | 7.08 |
| CHEMBL539803 | — | Ki | = | 83.9 | nM | 7.08 |
| CHEMBL328818 | — | Ki | = | 84.5 | nM | 7.07 |
| CHEMBL555655 | — | Ki | = | 103.0 | nM | 6.99 |
| CHEMBL94508 | — | Ki | = | 111.0 | nM | 6.96 |
| CHEMBL94738 | — | Ki | = | 128.0 | nM | 6.89 |
| CHEMBL94665 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL94711 | — | Ki | = | 278.0 | nM | 6.56 |
| CHEMBL554191 | — | Ki | = | 290.0 | nM | 6.54 |
| CHEMBL490 | PAROXETINE | Ki | = | 460.0 | nM | 6.34 |
| CHEMBL541308 | — | Ki | = | 652.0 | nM | 6.19 |
| CHEMBL94739 | FEMOXETINE | Ki | = | 1035.0 | nM | 5.99 |
| CHEMBL327790 | — | Ki | = | 1450.0 | nM | 5.84 |
| CHEMBL284305 | — | Ki | = | 1740.0 | nM | 5.76 |
| CHEMBL93035 | — | Ki | = | 2110.0 | nM | 5.68 |
| CHEMBL545724 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL96615 | — | Ki | = | 6180.0 | nM | 5.21 |
| CHEMBL11 | IMIPRAMINE | Ki | > | 10000.0 | nM | - |
| CHEMBL41 | FLUOXETINE | Ki | > | 2000.0 | nM | - |
| CHEMBL549 | CITALOPRAM | Ki | > | 10000.0 | nM | - |