Assay Detail
Binding
CHEMBL741870
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In vitro inhibition of binding of (-)-[3H]-NMS to Muscarinic acetylcholine receptor of rat cerebral cortex was determined
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Cerebral cortex |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Beta-lactam analogues of oxotremorine. 3- and 4-methyl-substituted 2-azetidinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.06 | 7.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51405 | — | — | 1 | 7.25 |
| CHEMBL154778 | — | — | 1 | 6.21 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.08 |
| CHEMBL345627 | — | — | 1 | 6.00 |
| CHEMBL109815 | — | — | 1 | 5.92 |
| CHEMBL48269 | — | — | 1 | 5.66 |
| CHEMBL347387 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51405 | — | Ki | = | 56.0 | nM | 7.25 |
| CHEMBL154778 | — | Ki | = | 610.0 | nM | 6.21 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL345627 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL109815 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL48269 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL347387 | — | Ki | = | 5000.0 | nM | 5.30 |