Assay Detail
Binding
CHEMBL741873
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M to muscarinic acetylcholine receptor in rat cerebral cortical membranes.
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Subcellular | Membrane |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 27 | 6.25 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64000 | — | — | 1 | 8.70 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.92 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.89 |
| CHEMBL12587 | MUSCARINE | — | 1 | 7.85 |
| CHEMBL310558 | — | — | 1 | 7.52 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 7.51 |
| CHEMBL315630 | — | — | 1 | 6.80 |
| CHEMBL315428 | — | — | 1 | 6.37 |
| CHEMBL84113 | — | — | 1 | 6.19 |
| CHEMBL314493 | — | — | 1 | 6.14 |
| CHEMBL313738 | — | — | 1 | 6.07 |
| CHEMBL85190 | — | — | 1 | 6.07 |
| CHEMBL294273 | — | — | 1 | 6.07 |
| CHEMBL316443 | — | — | 1 | 5.92 |
| CHEMBL315749 | — | — | 1 | 5.85 |
| CHEMBL440138 | — | — | 1 | 5.82 |
| CHEMBL313002 | — | — | 1 | 5.77 |
| CHEMBL314875 | — | — | 1 | 5.77 |
| CHEMBL82754 | — | — | 1 | 5.72 |
| CHEMBL82451 | — | — | 1 | 5.66 |
| CHEMBL82225 | — | — | 1 | 5.57 |
| CHEMBL408847 | — | — | 1 | 5.55 |
| CHEMBL82260 | — | — | 1 | 5.37 |
| CHEMBL82704 | — | — | 1 | 5.29 |
| CHEMBL314212 | — | — | 1 | 5.25 |
| CHEMBL312158 | — | — | 1 | 5.14 |
| CHEMBL85299 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64000 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL14 | CARBACHOL | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL12587 | MUSCARINE | Ki | = | 14.0 | nM | 7.85 |
| CHEMBL310558 | — | Ki | = | 30.0 | nM | 7.52 |
| CHEMBL7303 | ARECOLINE | Ki | = | 31.0 | nM | 7.51 |
| CHEMBL315630 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL315428 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL84113 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL314493 | — | Ki | = | 720.0 | nM | 6.14 |
| CHEMBL313738 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL85190 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL294273 | — | Ki | = | 860.0 | nM | 6.07 |
| CHEMBL316443 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL315749 | — | Ki | = | 1400.0 | nM | 5.85 |
| CHEMBL440138 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL313002 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL314875 | — | Ki | = | 1700.0 | nM | 5.77 |
| CHEMBL82754 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL82451 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL82225 | — | Ki | = | 2700.0 | nM | 5.57 |
| CHEMBL408847 | — | Ki | = | 2800.0 | nM | 5.55 |
| CHEMBL82260 | — | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL82704 | — | Ki | = | 5100.0 | nM | 5.29 |
| CHEMBL314212 | — | Ki | = | 5600.0 | nM | 5.25 |
| CHEMBL312158 | — | Ki | = | 7300.0 | nM | 5.14 |
| CHEMBL85299 | — | Ki | = | 14000.0 | nM | 4.85 |