Assay Detail
Binding
CHEMBL741875
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Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor of rat cerebral cortical membranes
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Subcellular | Membrane |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
6beta-Acyloxy(nor)tropanes: affinities for antagonist/agonist binding sites on transfected and native muscarinic receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 4.86 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL84113 | — | — | 1 | 6.10 |
| CHEMBL85190 | — | — | 1 | 5.75 |
| CHEMBL315428 | — | — | 1 | 5.66 |
| CHEMBL313738 | — | — | 1 | 5.07 |
| CHEMBL314493 | — | — | 1 | 4.64 |
| CHEMBL82754 | — | — | 1 | 4.60 |
| CHEMBL315630 | — | — | 1 | 4.52 |
| CHEMBL315749 | — | — | 1 | 4.51 |
| CHEMBL310558 | — | — | 1 | 4.50 |
| CHEMBL316443 | — | — | 1 | 4.47 |
| CHEMBL408847 | — | — | 1 | 4.28 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 4.24 |
| CHEMBL294273 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL84113 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL85190 | — | Ki | = | 1800.0 | nM | 5.75 |
| CHEMBL315428 | — | Ki | = | 2200.0 | nM | 5.66 |
| CHEMBL313738 | — | Ki | = | 8500.0 | nM | 5.07 |
| CHEMBL314493 | — | Ki | = | 23000.0 | nM | 4.64 |
| CHEMBL82754 | — | Ki | = | 25000.0 | nM | 4.60 |
| CHEMBL315630 | — | Ki | = | 30000.0 | nM | 4.52 |
| CHEMBL315749 | — | Ki | = | 31000.0 | nM | 4.51 |
| CHEMBL310558 | — | Ki | = | 32000.0 | nM | 4.50 |
| CHEMBL316443 | — | Ki | = | 34000.0 | nM | 4.47 |
| CHEMBL408847 | — | Ki | = | 53000.0 | nM | 4.28 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 58000.0 | nM | 4.24 |
| CHEMBL294273 | — | Ki | = | 280000.0 | nM | - |