Assay Detail
Functional
CHEMBL742200
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity towards electrically induced contractions in mouse vas deferens expressing delta opioid receptor
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Tissue | Vas deferens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships of cyclic opioid peptide analogues containing a phenylalanine residue in the 3-position.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.57 | 5.86 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL65047 | — | — | 1 | 5.86 |
| CHEMBL304431 | — | — | 1 | 5.86 |
| CHEMBL66039 | — | — | 1 | 5.78 |
| CHEMBL63235 | — | — | 1 | 5.69 |
| CHEMBL63407 | — | — | 1 | 5.41 |
| CHEMBL303513 | — | — | 1 | 5.32 |
| CHEMBL68177 | — | — | 1 | 5.07 |
| CHEMBL303418 | — | — | 1 | - |
| CHEMBL63972 | — | — | 1 | - |
| CHEMBL64949 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL65047 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL304431 | — | IC50 | = | 1380.0 | nM | 5.86 |
| CHEMBL66039 | — | IC50 | = | 1660.0 | nM | 5.78 |
| CHEMBL63235 | — | IC50 | = | 2030.0 | nM | 5.69 |
| CHEMBL63407 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL303513 | — | IC50 | = | 4810.0 | nM | 5.32 |
| CHEMBL68177 | — | IC50 | = | 8570.0 | nM | 5.07 |
| CHEMBL303418 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL63972 | — | IC50 | > | 8640.0 | nM | - |
| CHEMBL64949 | — | IC50 | > | 100000.0 | nM | - |