Assay Detail
Binding
CHEMBL742765
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Binding affinity against Muscarinic acetylcholine receptor M1 sites of rat
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Muscarinic acetylcholine receptor M1 (CHEMBL276) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Novel N-substituted 3 alpha-[bis(4'-fluorophenyl)methoxy]tropane analogues: selective ligands for the dopamine transporter.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.65 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | — | 1 | 8.05 |
| CHEMBL3084641 | — | — | 1 | 7.54 |
| CHEMBL417249 | — | — | 1 | 6.90 |
| CHEMBL440272 | — | — | 1 | 6.87 |
| CHEMBL12227 | — | — | 1 | 6.87 |
| CHEMBL11776 | — | — | 1 | 6.81 |
| CHEMBL3084927 | — | — | 1 | 6.62 |
| CHEMBL11493 | — | — | 1 | 6.60 |
| CHEMBL2308105 | — | — | 1 | 6.32 |
| CHEMBL11768 | — | — | 1 | 6.21 |
| CHEMBL12375 | — | — | 1 | 6.11 |
| CHEMBL135982 | — | — | 1 | 4.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL317757 | DIFLUOROBENZTROPINE | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL3084641 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL417249 | — | Ki | = | 126.0 | nM | 6.90 |
| CHEMBL440272 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL12227 | — | Ki | = | 136.0 | nM | 6.87 |
| CHEMBL11776 | — | Ki | = | 156.0 | nM | 6.81 |
| CHEMBL3084927 | — | Ki | = | 238.0 | nM | 6.62 |
| CHEMBL11493 | — | Ki | = | 251.0 | nM | 6.60 |
| CHEMBL2308105 | — | Ki | = | 483.0 | nM | 6.32 |
| CHEMBL11768 | — | Ki | = | 611.0 | nM | 6.21 |
| CHEMBL12375 | — | Ki | = | 773.0 | nM | 6.11 |
| CHEMBL135982 | — | Ki | = | 12300.0 | nM | 4.91 |