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Evidence Snapshot

Muscarinic acetylcholine receptor M1

CHEMBL276 SINGLE PROTEIN Rattus norvegicus
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T03:37:55Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL276
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Muscarinic acetylcholine receptor M1 as ChEMBL target CHEMBL276, mapped to UniProt P08482. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Muscarinic acetylcholine receptor M1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL276
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P08482
Muscarinic acetylcholine receptor M1
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Review-ready Target Rationale

Why Muscarinic acetylcholine receptor M1 matters

As of 2026-09-13

Muscarinic acetylcholine receptor M1 is reviewed as Muscarinic acetylcholine receptor M1 (UniProt P08482); the current evidence base includes 23 approved drugs, 2103 compounds, and 274 assays, with lead potency reaching pChEMBL 11.0.

Disease context
Disease signal

Disease relevance is not yet populated for this evidence card.

This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

ChEMBL target record
Activity base
Portfolio and assay base

ChEMBL currently tracks 23 approved drugs, 2103 compounds, and 274 assays for this target. The dominant activity type is KI. CHEMBL21905 is the current potency anchor at pChEMBL 11.0.

Use CHEMBL21905 as the tractability anchor when discussing potency (pChEMBL 11.0).

Activity source · ChEMBL 36 via Core Engine
23 approved pChEMBL 11.0
Source Guidance

Start with the right source

Pick the first block or linked source that matches the review question in front of you.

Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution

Start with the review rationale when you need to explain why Muscarinic acetylcholine receptor M1 matters before drilling into raw source blocks.

Jump to Review Rationale
Need stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Go back to the target snapshot when you need the naming and mapping contract behind UniProt P08482, not just the summarized rationale.

Open Protein Context
Need disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.

Open Disease Context

Snapshot State

No project snapshot selected. Export uses the live evidence card state.

2103
Total Compounds
274
Total Assays
23
Approved Drugs
IC50: 506.0, KI: 760.0, EC50: 258.0, KD: 19.0
Activity Types

pChEMBL Activity Distribution

Top 5 Inhibitors (by pChEMBL)

Structure Compound pChEMBL Type Phase
No preferred name
CHEMBL21905
 11.0 Ki —
No preferred name
CHEMBL21812
 10.7 Ki —
No preferred name
CHEMBL3298595
 10.7 Ki —
No preferred name
CHEMBL320611
 10.4 Ki —
No preferred name
CHEMBL3298599
 10.4 Ki —

Approved Drugs

Structure Compound First Approval
XANOMELINE
CHEMBL21536
 2024
TIOTROPIUM BROMIDE
CHEMBL3545181
 2004
SOLIFENACIN
CHEMBL1734
 2004
TOLTERODINE
CHEMBL1382
 1998
OLANZAPINE
CHEMBL715
 1996
CLOZAPINE
CHEMBL42
 1989
METHACHOLINE
CHEMBL978
 1986
SCOPOLAMINE
CHEMBL569713
 1979
OXYBUTYNIN
CHEMBL1231
 1975
PILOCARPINE
CHEMBL550
 1974
CARBACHOL
CHEMBL14
 1972
ATROPINE
CHEMBL517712
 1960
BENZTROPINE
CHEMBL1201203
 1954
DICYCLOMINE
CHEMBL1123
 1950
← Target Page
Source Header

ChEMBL 36 via Core Engine

Target Snapshot 2026-09-13T03:37:55Z
Source · ChEMBL 36 via Core Engine
ChEMBL ChEMBL 36 CHEMBL276