Assay Detail
Toxicity
CHEMBL743217
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Neurotoxicity was determined in cultured mouse cortical neurons
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Toxicity |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 3 | 4.75 | 4.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | — | 1 | 4.89 |
| CHEMBL73698 | — | — | 1 | 4.80 |
| CHEMBL72366 | — | — | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13378 | (R,S)-AMPA | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL73698 | — | EC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL72366 | — | EC50 | = | 27000.0 | nM | 4.57 |