Assay Detail
Functional
CHEMBL743372
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Neuroprotection was determined against NMDA induced cell death in cultured mouse cortical neuron.
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Novel NMDA antagonists: replacement of the pyridinium ring of 6,11-ethanobenzo[b]quinolizinium cations with heteroisoquinolinium cations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.13 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53944 | — | — | 1 | 7.38 |
| CHEMBL299087 | — | — | 1 | 7.35 |
| CHEMBL298994 | — | — | 1 | 7.30 |
| CHEMBL53067 | — | — | 1 | 7.28 |
| CHEMBL52124 | — | — | 1 | 7.22 |
| CHEMBL284237 | DIZOCILPINE | 2.0 | 1 | 7.17 |
| CHEMBL52782 | — | — | 1 | 6.76 |
| CHEMBL53273 | — | — | 1 | 6.59 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53944 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL299087 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL298994 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL53067 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL52124 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL284237 | DIZOCILPINE | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL52782 | — | IC50 | = | 173.0 | nM | 6.76 |
| CHEMBL53273 | — | IC50 | = | 257.0 | nM | 6.59 |