Assay Detail
Binding
CHEMBL743970
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of binding of [3H]N-methylscopolamine to muscarinic receptor (M3) in rat submaxillary gland homogenates
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor M3 (CHEMBL320) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Design, synthesis and biological activity of some tetraamines related to methoctramine and 4-DAMP
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.64 | 8.94 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | — | 1 | 8.94 |
| CHEMBL9967 | PIRENZEPINE | 2.0 | 1 | 6.76 |
| CHEMBL165220 | — | — | 1 | 6.52 |
| CHEMBL194216 | SPIROTRAMINE | — | 1 | 6.01 |
| CHEMBL27673 | METHOCTRAMINE | — | 1 | 5.96 |
| CHEMBL163901 | — | — | 1 | 5.67 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL76897 | 4-DAMP | Ki | = | 1.148 | nM | 8.94 |
| CHEMBL9967 | PIRENZEPINE | Ki | = | 173.78 | nM | 6.76 |
| CHEMBL165220 | — | Ki | = | 302.0 | nM | 6.52 |
| CHEMBL194216 | SPIROTRAMINE | Ki | = | 977.24 | nM | 6.01 |
| CHEMBL27673 | METHOCTRAMINE | Ki | = | 1096.48 | nM | 5.96 |
| CHEMBL163901 | — | Ki | = | 2137.96 | nM | 5.67 |