Assay Detail
Binding
CHEMBL743978
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Displacement of [3H]QNB from rat ileum Muscarinic acetylcholine receptor
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Ileum |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Synthesis of some 3-(1-azabicyclo[2.2.2]octyl) 3-amino-2-hydroxy-2-phenylpropionates: profile of antimuscarinic efficacy and selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 12 | 6.09 | 9.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | 4.0 | 1 | 9.35 |
| CHEMBL2115342 | — | — | 1 | 8.22 |
| CHEMBL1202960 | — | — | 1 | 6.80 |
| CHEMBL1202955 | — | — | 1 | 6.71 |
| CHEMBL1202954 | — | — | 1 | 5.79 |
| CHEMBL1202958 | — | — | 1 | 5.62 |
| CHEMBL557216 | — | — | 1 | 5.40 |
| CHEMBL320755 | — | — | 1 | 5.28 |
| CHEMBL1202956 | — | — | 1 | 5.08 |
| CHEMBL1202957 | — | — | 1 | 5.04 |
| CHEMBL1202959 | — | — | 1 | 4.91 |
| CHEMBL1202961 | — | — | 1 | 4.90 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL517712 | ATROPINE | Ki | = | 0.45 | nM | 9.35 |
| CHEMBL2115342 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL1202960 | — | Ki | = | 158.0 | nM | 6.80 |
| CHEMBL1202955 | — | Ki | = | 195.0 | nM | 6.71 |
| CHEMBL1202954 | — | Ki | = | 1620.0 | nM | 5.79 |
| CHEMBL1202958 | — | Ki | = | 2380.0 | nM | 5.62 |
| CHEMBL557216 | — | Ki | = | 3980.0 | nM | 5.40 |
| CHEMBL320755 | — | Ki | = | 5240.0 | nM | 5.28 |
| CHEMBL1202956 | — | Ki | = | 8280.0 | nM | 5.08 |
| CHEMBL1202957 | — | Ki | = | 9190.0 | nM | 5.04 |
| CHEMBL1202959 | — | Ki | = | 12230.0 | nM | 4.91 |
| CHEMBL1202961 | — | Ki | = | 12600.0 | nM | 4.90 |