Assay Detail
Functional
CHEMBL743981
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Compound was tested for its potency against Muscarinic acetylcholine receptor in guinea pig ileum
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Cavia porcellus |
| Tissue | Ileum |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL2094109) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Resolved pyrrolidine, piperidine, and perhydroazepine analogues of the muscarinic agent N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.18 | 7.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1788202 | — | — | 1 | 7.03 |
| CHEMBL14 | CARBACHOL | 4.0 | 1 | 7.00 |
| CHEMBL108140 | — | — | 1 | 5.55 |
| CHEMBL111327 | — | — | 1 | 5.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1788202 | — | EC50 | = | 94.0 | nM | 7.03 |
| CHEMBL14 | CARBACHOL | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL108140 | — | EC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL111327 | — | EC50 | = | 7500.0 | nM | 5.12 |