Assay Detail
Functional
CHEMBL743989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity for murine PPAR alpha receptor in transcriptional activation assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Peroxisome proliferator-activated receptor alpha (CHEMBL2128) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
The PPARs: from orphan receptors to drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 5.57 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | — | 1 | 8.30 |
| CHEMBL435278 | — | — | 1 | 6.57 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 6.20 |
| CHEMBL306229 | — | — | 1 | 6.03 |
| CHEMBL293526 | REGLITAZAR | 2.0 | 1 | 5.37 |
| CHEMBL278994 | L-796449 | — | 1 | 5.12 |
| CHEMBL24458 | — | — | 1 | 5.00 |
| CHEMBL672 | FENOFIBRATE | 4.0 | 1 | 4.75 |
| CHEMBL565 | CLOFIBRATE | 4.0 | 1 | 4.30 |
| CHEMBL264374 | BEZAFIBRATE | 3.0 | 1 | 4.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278590 | GSK-9578 | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL435278 | — | EC50 | = | 270.0 | nM | 6.57 |
| CHEMBL295416 | PIRINIXIC ACID | EC50 | = | 630.0 | nM | 6.20 |
| CHEMBL306229 | — | EC50 | = | 930.0 | nM | 6.03 |
| CHEMBL293526 | REGLITAZAR | EC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL278994 | L-796449 | EC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL24458 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL672 | FENOFIBRATE | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL565 | CLOFIBRATE | EC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL264374 | BEZAFIBRATE | EC50 | = | 90000.0 | nM | 4.05 |