Assay Detail
Functional
CHEMBL744105
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Inhibitory activity against NCI-H647 cell line using MTT assay(mutant p53)
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H647 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Antitumor polycyclic acridines. 7. Synthesis and biological properties of DNA affinic tetra- and pentacyclic acridines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 6.27 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | 4.0 | 1 | 7.16 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 7.10 |
| CHEMBL41700 | — | — | 1 | 7.10 |
| CHEMBL43453 | — | — | 1 | 6.92 |
| CHEMBL41526 | — | — | 1 | 6.27 |
| CHEMBL38451 | — | — | 1 | 6.10 |
| CHEMBL41701 | — | — | 1 | 6.02 |
| CHEMBL291263 | — | — | 1 | 5.78 |
| CHEMBL41174 | — | — | 1 | 5.66 |
| CHEMBL43229 | — | — | 1 | 5.54 |
| CHEMBL41863 | — | — | 1 | 5.28 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43 | AMSACRINE | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL41700 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL43453 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL41526 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL38451 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL41701 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL291263 | — | IC50 | = | 1680.0 | nM | 5.78 |
| CHEMBL41174 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL43229 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL41863 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL53463 | DOXORUBICIN | IC50 | < | 1.0 | nM | - |