Assay Detail
Binding
CHEMBL744115
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Tested for Inhibitory concentration against human N-myristoyltransferase (NMT) in radiochemical HPLC end point assay with peptide GNAASARR-NH2 and [3H]myristoyl-CoA radioligand at 1 uM
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Replacements for lysine in l-seryl-l-lysyl dipeptide amide inhibitors of candida albicans myristoyl-CoA:protein N-myristoyltransferase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.12 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL33289 | — | — | 1 | 6.30 |
| CHEMBL331272 | — | — | 1 | 6.00 |
| CHEMBL6269 | SC-58272 | — | 1 | 4.85 |
| CHEMBL279641 | — | — | 1 | 4.76 |
| CHEMBL341147 | — | — | 1 | 4.54 |
| CHEMBL125031 | — | — | 1 | 4.28 |
| CHEMBL340659 | — | — | 1 | - |
| CHEMBL124696 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL33289 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL331272 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL6269 | SC-58272 | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL279641 | — | IC50 | = | 17200.0 | nM | 4.76 |
| CHEMBL341147 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL125031 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL340659 | — | IC50 | >= | 200000.0 | nM | - |
| CHEMBL124696 | — | IC50 | > | 10000.0 | nM | - |