Assay Detail
Binding
CHEMBL744118
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Inhibition activity against N-myristoyltransferase (NMT) of human.
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Design and synthesis of novel imidazole-substituted dipeptide amides as potent and selective inhibitors of Candida albicans myristoylCoA:protein N-myristoyltransferase and identification of related tripeptide inhibitors with mechanism-based antifungal activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.04 | 6.31 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL291811 | — | — | 1 | 6.31 |
| CHEMBL59835 | — | — | 1 | 5.81 |
| CHEMBL188653 | — | — | 1 | 5.10 |
| CHEMBL291791 | — | — | 1 | 5.09 |
| CHEMBL299249 | — | — | 1 | 4.95 |
| CHEMBL6269 | SC-58272 | — | 1 | 4.85 |
| CHEMBL294596 | — | — | 1 | 4.80 |
| CHEMBL89727 | — | — | 1 | 4.64 |
| CHEMBL88093 | — | — | 1 | 4.55 |
| CHEMBL62081 | — | — | 1 | 4.31 |
| CHEMBL91048 | — | — | 1 | - |
| CHEMBL313084 | — | — | 1 | - |
| CHEMBL313161 | — | — | 1 | - |
| CHEMBL86687 | — | — | 1 | - |
| CHEMBL89452 | — | — | 1 | - |
| CHEMBL86856 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL291811 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL59835 | — | IC50 | = | 1540.0 | nM | 5.81 |
| CHEMBL188653 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL291791 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL299249 | — | IC50 | = | 11350.0 | nM | 4.95 |
| CHEMBL6269 | SC-58272 | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL294596 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL89727 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL88093 | — | IC50 | = | 28200.0 | nM | 4.55 |
| CHEMBL62081 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL91048 | — | IC50 | = | 142000.0 | nM | - |
| CHEMBL313084 | — | IC50 | = | 119500.0 | nM | - |
| CHEMBL313161 | — | IC50 | = | 809500.0 | nM | - |
| CHEMBL86687 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL89452 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL86856 | — | IC50 | = | 840000.0 | nM | - |