Assay Detail
Binding
CHEMBL744129
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Compound was evaluated for the binding affinity towards mu opioid receptor in rat brain homogenates using [3H]DAMGO as radioligand
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Brain |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 14-alkoxymorphinans. 14.1 14-ethoxy-5-methyl substituted indolomorphinans with opioid receptor selectivity
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 6.82 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | — | 1 | 7.52 |
| CHEMBL558004 | — | — | 1 | 7.41 |
| CHEMBL608245 | — | — | 1 | 6.18 |
| CHEMBL608246 | — | — | 1 | 6.15 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL567175 | NALTRINDOLE | Ki | = | 30.4 | nM | 7.52 |
| CHEMBL558004 | — | Ki | = | 38.7 | nM | 7.41 |
| CHEMBL608245 | — | Ki | = | 667.0 | nM | 6.18 |
| CHEMBL608246 | — | Ki | = | 715.0 | nM | 6.15 |