Assay Detail
Binding
CHEMBL744134
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In vitro binding affinity to the Muscarinic acetylcholine receptor by displacing [3H]-QNB from the rat heart tissues
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Heart |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Annulated heterocyclic bioisosteres of norarecoline. Synthesis and molecular pharmacology at five recombinant human muscarinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.62 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL69306 | — | — | 1 | 7.09 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 7.08 |
| CHEMBL69305 | — | — | 1 | 6.85 |
| CHEMBL304142 | — | — | 1 | 6.46 |
| CHEMBL305264 | — | — | 1 | 6.44 |
| CHEMBL7303 | ARECOLINE | -1.0 | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL69306 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL69305 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL304142 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL305264 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL7303 | ARECOLINE | IC50 | = | 1700.0 | nM | 5.77 |