Assay Detail
Binding
CHEMBL744144
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Inhibition of radioligand [3H]QNB binding (competitive inhibition) to muscarinic acetylcholine receptor in the rat forebrain in the absence of zinc
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 5.07 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.18 |
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | 6.03 |
| CHEMBL154030 | — | — | 1 | 5.80 |
| CHEMBL157914 | — | — | 1 | 5.58 |
| CHEMBL345535 | — | — | 1 | 5.52 |
| CHEMBL347239 | — | — | 1 | 5.46 |
| CHEMBL350903 | — | — | 1 | 5.40 |
| CHEMBL153830 | — | — | 1 | 5.27 |
| CHEMBL155466 | — | — | 1 | 5.19 |
| CHEMBL154576 | — | — | 1 | 5.19 |
| CHEMBL346314 | — | — | 1 | 5.16 |
| CHEMBL155252 | — | — | 1 | 5.16 |
| CHEMBL350442 | — | — | 1 | 5.06 |
| CHEMBL154062 | — | — | 1 | 5.05 |
| CHEMBL154961 | — | — | 1 | 5.02 |
| CHEMBL154501 | — | — | 1 | 4.96 |
| CHEMBL157442 | — | — | 1 | 4.96 |
| CHEMBL155012 | — | — | 1 | 4.89 |
| CHEMBL154821 | — | — | 1 | 4.89 |
| CHEMBL154520 | — | — | 1 | 4.85 |
| CHEMBL347928 | — | — | 1 | 4.64 |
| CHEMBL154921 | — | — | 1 | 4.62 |
| CHEMBL154109 | — | — | 1 | 4.62 |
| CHEMBL156895 | — | — | 1 | 4.58 |
| CHEMBL155606 | — | — | 1 | 4.48 |
| CHEMBL154759 | — | — | 1 | 4.37 |
| CHEMBL156601 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL29835 | BESIPIRDINE | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL154030 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL157914 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL345535 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL347239 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL350903 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL153830 | — | IC50 | = | 5400.0 | nM | 5.27 |
| CHEMBL155466 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL154576 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL346314 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL155252 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL350442 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL154062 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL154961 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL154501 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL157442 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL155012 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL154821 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL154520 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL347928 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL154921 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL154109 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL156895 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL155606 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL154759 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL156601 | — | IC50 | = | 86000.0 | nM | 4.07 |