Assay Detail
Binding
CHEMBL744145
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Inhibition of radioligand [3H]QNB binding to muscarinic acetylcholine receptor in the rat forebrain in the presence of zinc
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Substituted (pyrroloamino)pyridines: potential agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 29 | 4.75 | 6.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | 4.0 | 1 | 6.52 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 5.57 |
| CHEMBL29835 | BESIPIRDINE | 2.0 | 1 | 5.52 |
| CHEMBL345535 | — | — | 1 | 5.09 |
| CHEMBL157914 | — | — | 1 | 5.07 |
| CHEMBL350903 | — | — | 1 | 4.90 |
| CHEMBL347239 | — | — | 1 | 4.87 |
| CHEMBL154030 | — | — | 1 | 4.77 |
| CHEMBL350442 | — | — | 1 | 4.75 |
| CHEMBL154576 | — | — | 1 | 4.67 |
| CHEMBL155466 | — | — | 1 | 4.66 |
| CHEMBL154501 | — | — | 1 | 4.62 |
| CHEMBL346314 | — | — | 1 | 4.57 |
| CHEMBL153830 | — | — | 1 | 4.48 |
| CHEMBL156895 | — | — | 1 | 4.41 |
| CHEMBL155252 | — | — | 1 | 4.37 |
| CHEMBL154520 | — | — | 1 | 4.29 |
| CHEMBL154921 | — | — | 1 | 4.28 |
| CHEMBL154821 | — | — | 1 | 4.16 |
| CHEMBL155012 | — | — | 1 | 4.12 |
| CHEMBL154062 | — | — | 1 | 4.12 |
| CHEMBL156601 | — | — | 1 | - |
| CHEMBL154759 | — | — | 1 | - |
| CHEMBL154109 | — | — | 1 | - |
| CHEMBL346304 | — | — | 1 | - |
| CHEMBL157442 | — | — | 1 | - |
| CHEMBL155606 | — | — | 1 | - |
| CHEMBL154961 | — | — | 1 | - |
| CHEMBL347928 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL629 | AMITRIPTYLINE | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL7634 | OXOTREMORINE | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL29835 | BESIPIRDINE | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL345535 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL157914 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL350903 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL347239 | — | IC50 | = | 13500.0 | nM | 4.87 |
| CHEMBL154030 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL350442 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL154576 | — | IC50 | = | 21500.0 | nM | 4.67 |
| CHEMBL155466 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL154501 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL346314 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL153830 | — | IC50 | = | 33000.0 | nM | 4.48 |
| CHEMBL156895 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL155252 | — | IC50 | = | 43000.0 | nM | 4.37 |
| CHEMBL154520 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL154921 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL154821 | — | IC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL155012 | — | IC50 | = | 76200.0 | nM | 4.12 |
| CHEMBL154062 | — | IC50 | = | 76400.0 | nM | 4.12 |
| CHEMBL156601 | — | IC50 | = | 721000.0 | nM | - |
| CHEMBL154759 | — | IC50 | = | 184000.0 | nM | - |
| CHEMBL154109 | — | IC50 | = | 295000.0 | nM | - |
| CHEMBL346304 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL157442 | — | IC50 | = | 138000.0 | nM | - |
| CHEMBL155606 | — | IC50 | = | 185000.0 | nM | - |
| CHEMBL154961 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL347928 | — | IC50 | = | 173000.0 | nM | - |