Assay Detail
Binding
CHEMBL744146
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Muscarinic acetylcholine receptor binding (rat cortical membranes) was determined by displacement of [3H]quinuclidinyl benzylate [3H]QNB)
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.29 | 5.80 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61772 | — | — | 1 | 5.80 |
| CHEMBL1788226 | — | — | 1 | 5.35 |
| CHEMBL111526 | — | — | 1 | 5.24 |
| CHEMBL111659 | ALTINICLINE | 2.0 | 1 | 5.05 |
| CHEMBL111580 | — | — | 1 | 5.00 |
| CHEMBL3 | NICOTINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61772 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL1788226 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL111526 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL111659 | ALTINICLINE | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL111580 | — | IC50 | = | 10100.0 | nM | 5.00 |
| CHEMBL3 | NICOTINE | IC50 | = | 360000.0 | nM | - |