Assay Detail
Functional
CHEMBL744171
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Reuptake inhibitory activity against NE transporter
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and pharmacological evaluation of 3-(3,4-dichlorophenyl)-1-indanamine derivatives as nonselective ligands for biogenic amine transporters.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.22 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | 2.0 | 1 | 7.96 |
| CHEMBL89142 | — | — | 1 | 7.70 |
| CHEMBL543372 | — | — | 1 | 7.47 |
| CHEMBL89752 | — | — | 1 | 6.80 |
| CHEMBL554565 | — | — | 1 | 6.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL296602 | INDATRALINE | Ki | = | 11.0 | nM | 7.96 |
| CHEMBL89142 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL543372 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL89752 | — | Ki | = | 160.0 | nM | 6.80 |
| CHEMBL554565 | — | Ki | = | 650.0 | nM | 6.19 |