Assay Detail
Binding
CHEMBL744173
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was tested for binding affinity nisoxatine ligand
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl]carbazole (rimcazole) analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.38 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2112789 | — | — | 1 | 5.89 |
| CHEMBL275707 | RIMCAZOLE | 2.0 | 1 | 5.67 |
| CHEMBL2112783 | — | — | 1 | 5.60 |
| CHEMBL2112787 | — | — | 1 | 5.44 |
| CHEMBL324896 | — | — | 1 | 5.38 |
| CHEMBL2112788 | — | — | 1 | 5.34 |
| CHEMBL2112784 | — | — | 1 | 5.17 |
| CHEMBL2112760 | — | — | 1 | 5.03 |
| CHEMBL2112791 | — | — | 1 | 4.86 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2112789 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL275707 | RIMCAZOLE | Ki | = | 2160.0 | nM | 5.67 |
| CHEMBL2112783 | — | Ki | = | 2490.0 | nM | 5.60 |
| CHEMBL2112787 | — | Ki | = | 3640.0 | nM | 5.44 |
| CHEMBL324896 | — | Ki | = | 4120.0 | nM | 5.38 |
| CHEMBL2112788 | — | Ki | = | 4580.0 | nM | 5.34 |
| CHEMBL2112784 | — | Ki | = | 6810.0 | nM | 5.17 |
| CHEMBL2112760 | — | Ki | = | 9370.0 | nM | 5.03 |
| CHEMBL2112791 | — | Ki | = | 13900.0 | nM | 4.86 |